Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2.
Identifieur interne : 000D96 ( Main/Exploration ); précédent : 000D95; suivant : 000D97Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2.
Auteurs : Angela Chaparro-Garcia [Royaume-Uni] ; Simon Schwizer [Royaume-Uni] ; Jan Sklenar [Royaume-Uni] ; Kentaro Yoshida [Royaume-Uni] ; Benjamin Petre [Royaume-Uni] ; Jorunn I B. Bos [Royaume-Uni] ; Sebastian Schornack [Royaume-Uni] ; Alexandra M E. Jones [Royaume-Uni] ; Tolga O. Bozkurt [Royaume-Uni] ; Sophien Kamoun [Royaume-Uni]Source :
- PloS one [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Arabidopsis (génétique), Arabidopsis (immunologie), Arabidopsis (microbiologie), Dynamines (génétique), Dynamines (immunologie), Dynamines (métabolisme), Endocytose (immunologie), Facteurs de virulence (immunologie), Facteurs de virulence (métabolisme), Immunité des plantes (génétique), Molécules contenant des motifs associés aux pathogènes (métabolisme), Mort cellulaire (génétique), Phytophthora infestans (génétique), Phytophthora infestans (immunologie), Phytophthora infestans (pathogénicité), Protein kinases (génétique), Protein kinases (immunologie), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (immunologie), Protéines (métabolisme), Protéines d'Arabidopsis (génétique), Protéines d'Arabidopsis (immunologie), Protéines d'Arabidopsis (métabolisme), Tabac (génétique), Tabac (immunologie), Tabac (microbiologie), Ubiquitin-protein ligases (métabolisme), Voies et réseaux métaboliques (MeSH), Végétaux génétiquement modifiés (MeSH).
- MESH :
- génétique : Arabidopsis, Dynamines, Immunité des plantes, Mort cellulaire, Phytophthora infestans, Protein kinases, Protein-Serine-Threonine Kinases, Protéines d'Arabidopsis, Tabac.
- immunologie : Arabidopsis, Dynamines, Endocytose, Facteurs de virulence, Phytophthora infestans, Protein kinases, Protein-Serine-Threonine Kinases, Protéines d'Arabidopsis, Tabac.
- microbiologie : Arabidopsis, Tabac.
- métabolisme : Dynamines, Facteurs de virulence, Molécules contenant des motifs associés aux pathogènes, Protéines, Protéines d'Arabidopsis, Ubiquitin-protein ligases.
- pathogénicité : Phytophthora infestans.
- Voies et réseaux métaboliques, Végétaux génétiquement modifiés.
English descriptors
- KwdEn :
- Arabidopsis (genetics), Arabidopsis (immunology), Arabidopsis (microbiology), Arabidopsis Proteins (genetics), Arabidopsis Proteins (immunology), Arabidopsis Proteins (metabolism), Cell Death (genetics), Dynamins (genetics), Dynamins (immunology), Dynamins (metabolism), Endocytosis (immunology), Metabolic Networks and Pathways (MeSH), Pathogen-Associated Molecular Pattern Molecules (metabolism), Phytophthora infestans (genetics), Phytophthora infestans (immunology), Phytophthora infestans (pathogenicity), Plant Immunity (genetics), Plants, Genetically Modified (MeSH), Protein Kinases (genetics), Protein Kinases (immunology), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (immunology), Proteins (metabolism), Tobacco (genetics), Tobacco (immunology), Tobacco (microbiology), Ubiquitin-Protein Ligases (metabolism), Virulence Factors (immunology), Virulence Factors (metabolism).
- MESH :
- chemical , genetics : Arabidopsis Proteins, Dynamins, Protein Kinases, Protein-Serine-Threonine Kinases.
- genetics : Arabidopsis, Cell Death, Phytophthora infestans, Plant Immunity, Tobacco.
- immunology : Arabidopsis, Arabidopsis Proteins, Dynamins, Endocytosis, Phytophthora infestans, Protein Kinases, Protein-Serine-Threonine Kinases, Tobacco, Virulence Factors.
- chemical , metabolism : Arabidopsis Proteins, Dynamins, Pathogen-Associated Molecular Pattern Molecules, Proteins, Ubiquitin-Protein Ligases, Virulence Factors.
- microbiology : Arabidopsis, Tobacco.
- pathogenicity : Phytophthora infestans.
- Metabolic Networks and Pathways, Plants, Genetically Modified.
Abstract
Pathogens utilize effectors to suppress basal plant defense known as PTI (Pathogen-associated molecular pattern-triggered immunity). However, our knowledge of PTI suppression by filamentous plant pathogens, i.e. fungi and oomycetes, remains fragmentary. Previous work revealed that the co-receptor BAK1/SERK3 contributes to basal immunity against the potato pathogen Phytophthora infestans. Moreover BAK1/SERK3 is required for the cell death induced by P. infestans elicitin INF1, a protein with characteristics of PAMPs. The P. infestans host-translocated RXLR-WY effector AVR3a is known to supress INF1-mediated cell death by binding the plant E3 ligase CMPG1. In contrast, AVR3aKI-Y147del, a deletion mutant of the C-terminal tyrosine of AVR3a, fails to bind CMPG1 and does not suppress INF1-mediated cell death. Here, we studied the extent to which AVR3a and its variants perturb additional BAK1/SERK3-dependent PTI responses in N. benthamiana using the elicitor/receptor pair flg22/FLS2 as a model. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. Interestingly, silencing of DRP2 impaired ligand-induced FLS2 internalization but did not affect internalization of the growth receptor BRI1. Our results suggest that AVR3a associates with a key cellular trafficking and membrane-remodeling complex involved in immune receptor-mediated endocytosis. We conclude that AVR3a is a multifunctional effector that can suppress BAK1/SERK3-mediated immunity through at least two different pathways.
DOI: 10.1371/journal.pone.0137071
PubMed: 26348328
PubMed Central: PMC4562647
Affiliations:
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Bos</name><affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sainsbury Laboratory, Norwich Research Park, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Schornack, Sebastian" sort="Schornack, Sebastian" uniqKey="Schornack S" first="Sebastian" last="Schornack">Sebastian Schornack</name><affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sainsbury Laboratory, Norwich Research Park, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Alexandra M E" sort="Jones, Alexandra M E" uniqKey="Jones A" first="Alexandra M E" last="Jones">Alexandra M E. Jones</name><affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sainsbury Laboratory, Norwich Research Park, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Bozkurt, Tolga O" sort="Bozkurt, Tolga O" uniqKey="Bozkurt T" first="Tolga O" last="Bozkurt">Tolga O. Bozkurt</name><affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sainsbury Laboratory, Norwich Research Park, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Kamoun, Sophien" sort="Kamoun, Sophien" uniqKey="Kamoun S" first="Sophien" last="Kamoun">Sophien Kamoun</name><affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sainsbury Laboratory, Norwich Research Park, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arabidopsis (genetics)</term><term>Arabidopsis (immunology)</term><term>Arabidopsis (microbiology)</term><term>Arabidopsis Proteins (genetics)</term><term>Arabidopsis Proteins (immunology)</term><term>Arabidopsis Proteins (metabolism)</term><term>Cell Death (genetics)</term><term>Dynamins (genetics)</term><term>Dynamins (immunology)</term><term>Dynamins (metabolism)</term><term>Endocytosis (immunology)</term><term>Metabolic Networks and Pathways (MeSH)</term><term>Pathogen-Associated Molecular Pattern Molecules (metabolism)</term><term>Phytophthora infestans (genetics)</term><term>Phytophthora infestans (immunology)</term><term>Phytophthora infestans (pathogenicity)</term><term>Plant Immunity (genetics)</term><term>Plants, Genetically Modified (MeSH)</term><term>Protein Kinases (genetics)</term><term>Protein Kinases (immunology)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Protein-Serine-Threonine Kinases (immunology)</term><term>Proteins (metabolism)</term><term>Tobacco (genetics)</term><term>Tobacco (immunology)</term><term>Tobacco (microbiology)</term><term>Ubiquitin-Protein Ligases (metabolism)</term><term>Virulence Factors (immunology)</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Arabidopsis (génétique)</term><term>Arabidopsis (immunologie)</term><term>Arabidopsis (microbiologie)</term><term>Dynamines (génétique)</term><term>Dynamines (immunologie)</term><term>Dynamines (métabolisme)</term><term>Endocytose (immunologie)</term><term>Facteurs de virulence (immunologie)</term><term>Facteurs de virulence (métabolisme)</term><term>Immunité des plantes (génétique)</term><term>Molécules contenant des motifs associés aux pathogènes (métabolisme)</term><term>Mort cellulaire (génétique)</term><term>Phytophthora infestans (génétique)</term><term>Phytophthora infestans (immunologie)</term><term>Phytophthora infestans (pathogénicité)</term><term>Protein kinases (génétique)</term><term>Protein kinases (immunologie)</term><term>Protein-Serine-Threonine Kinases (génétique)</term><term>Protein-Serine-Threonine Kinases (immunologie)</term><term>Protéines (métabolisme)</term><term>Protéines d'Arabidopsis (génétique)</term><term>Protéines d'Arabidopsis (immunologie)</term><term>Protéines d'Arabidopsis (métabolisme)</term><term>Tabac (génétique)</term><term>Tabac (immunologie)</term><term>Tabac (microbiologie)</term><term>Ubiquitin-protein ligases (métabolisme)</term><term>Voies et réseaux métaboliques (MeSH)</term><term>Végétaux génétiquement modifiés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arabidopsis Proteins</term><term>Dynamins</term><term>Protein Kinases</term><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabidopsis</term><term>Cell Death</term><term>Phytophthora infestans</term><term>Plant Immunity</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arabidopsis</term><term>Dynamines</term><term>Immunité des plantes</term><term>Mort cellulaire</term><term>Phytophthora infestans</term><term>Protein kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines d'Arabidopsis</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Arabidopsis</term><term>Dynamines</term><term>Endocytose</term><term>Facteurs de virulence</term><term>Phytophthora infestans</term><term>Protein kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines d'Arabidopsis</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arabidopsis</term><term>Arabidopsis Proteins</term><term>Dynamins</term><term>Endocytosis</term><term>Phytophthora infestans</term><term>Protein Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Tobacco</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Arabidopsis Proteins</term><term>Dynamins</term><term>Pathogen-Associated Molecular Pattern Molecules</term><term>Proteins</term><term>Ubiquitin-Protein Ligases</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Arabidopsis</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Arabidopsis</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dynamines</term><term>Facteurs de virulence</term><term>Molécules contenant des motifs associés aux pathogènes</term><term>Protéines</term><term>Protéines d'Arabidopsis</term><term>Ubiquitin-protein ligases</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Metabolic Networks and Pathways</term><term>Plants, Genetically Modified</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Voies et réseaux métaboliques</term><term>Végétaux génétiquement modifiés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathogens utilize effectors to suppress basal plant defense known as PTI (Pathogen-associated molecular pattern-triggered immunity). However, our knowledge of PTI suppression by filamentous plant pathogens, i.e. fungi and oomycetes, remains fragmentary. Previous work revealed that the co-receptor BAK1/SERK3 contributes to basal immunity against the potato pathogen Phytophthora infestans. Moreover BAK1/SERK3 is required for the cell death induced by P. infestans elicitin INF1, a protein with characteristics of PAMPs. The P. infestans host-translocated RXLR-WY effector AVR3a is known to supress INF1-mediated cell death by binding the plant E3 ligase CMPG1. In contrast, AVR3aKI-Y147del, a deletion mutant of the C-terminal tyrosine of AVR3a, fails to bind CMPG1 and does not suppress INF1-mediated cell death. Here, we studied the extent to which AVR3a and its variants perturb additional BAK1/SERK3-dependent PTI responses in N. benthamiana using the elicitor/receptor pair flg22/FLS2 as a model. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. Interestingly, silencing of DRP2 impaired ligand-induced FLS2 internalization but did not affect internalization of the growth receptor BRI1. Our results suggest that AVR3a associates with a key cellular trafficking and membrane-remodeling complex involved in immune receptor-mediated endocytosis. We conclude that AVR3a is a multifunctional effector that can suppress BAK1/SERK3-mediated immunity through at least two different pathways. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26348328</PMID><DateCompleted><Year>2016</Year><Month>05</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Phytophthora infestans RXLR-WY Effector AVR3a Associates with Dynamin-Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2.</ArticleTitle><Pagination><MedlinePgn>e0137071</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0137071</ELocationID><Abstract><AbstractText>Pathogens utilize effectors to suppress basal plant defense known as PTI (Pathogen-associated molecular pattern-triggered immunity). However, our knowledge of PTI suppression by filamentous plant pathogens, i.e. fungi and oomycetes, remains fragmentary. Previous work revealed that the co-receptor BAK1/SERK3 contributes to basal immunity against the potato pathogen Phytophthora infestans. Moreover BAK1/SERK3 is required for the cell death induced by P. infestans elicitin INF1, a protein with characteristics of PAMPs. The P. infestans host-translocated RXLR-WY effector AVR3a is known to supress INF1-mediated cell death by binding the plant E3 ligase CMPG1. In contrast, AVR3aKI-Y147del, a deletion mutant of the C-terminal tyrosine of AVR3a, fails to bind CMPG1 and does not suppress INF1-mediated cell death. Here, we studied the extent to which AVR3a and its variants perturb additional BAK1/SERK3-dependent PTI responses in N. benthamiana using the elicitor/receptor pair flg22/FLS2 as a model. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2), a plant GTPase implicated in receptor-mediated endocytosis. Interestingly, silencing of DRP2 impaired ligand-induced FLS2 internalization but did not affect internalization of the growth receptor BRI1. Our results suggest that AVR3a associates with a key cellular trafficking and membrane-remodeling complex involved in immune receptor-mediated endocytosis. We conclude that AVR3a is a multifunctional effector that can suppress BAK1/SERK3-mediated immunity through at least two different pathways. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chaparro-Garcia</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwizer</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sklenar</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Kentaro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petre</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bos</LastName><ForeName>Jorunn I B</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schornack</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Alexandra M E</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozkurt</LastName><ForeName>Tolga O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamoun</LastName><ForeName>Sophien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal 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MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055750" MajorTopicYN="N">Phytophthora infestans</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011494" MajorTopicYN="N">Protein Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017346" 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IdType="pubmed">23532067</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Chaparro Garcia, Angela" sort="Chaparro Garcia, Angela" uniqKey="Chaparro Garcia A" first="Angela" last="Chaparro-Garcia">Angela Chaparro-Garcia</name></noRegion><name sortKey="Bos, Jorunn I B" sort="Bos, Jorunn I B" uniqKey="Bos J" first="Jorunn I B" last="Bos">Jorunn I B. Bos</name><name sortKey="Bozkurt, Tolga O" sort="Bozkurt, Tolga O" uniqKey="Bozkurt T" first="Tolga O" last="Bozkurt">Tolga O. Bozkurt</name><name sortKey="Jones, Alexandra M E" sort="Jones, Alexandra M E" uniqKey="Jones A" first="Alexandra M E" last="Jones">Alexandra M E. Jones</name><name sortKey="Kamoun, Sophien" sort="Kamoun, Sophien" uniqKey="Kamoun S" first="Sophien" last="Kamoun">Sophien Kamoun</name><name sortKey="Petre, Benjamin" sort="Petre, Benjamin" uniqKey="Petre B" first="Benjamin" last="Petre">Benjamin Petre</name><name sortKey="Schornack, Sebastian" sort="Schornack, Sebastian" uniqKey="Schornack S" first="Sebastian" last="Schornack">Sebastian Schornack</name><name sortKey="Schwizer, Simon" sort="Schwizer, Simon" uniqKey="Schwizer S" first="Simon" last="Schwizer">Simon Schwizer</name><name sortKey="Sklenar, Jan" sort="Sklenar, Jan" uniqKey="Sklenar J" first="Jan" last="Sklenar">Jan Sklenar</name><name sortKey="Yoshida, Kentaro" sort="Yoshida, Kentaro" uniqKey="Yoshida K" first="Kentaro" last="Yoshida">Kentaro Yoshida</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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